Question for AIIMS CRE Assistant Research Officer / Research Assistant 2026 - Quiz / Questions / MCQ

Objective Questions

Latest AIIMS CRE ARO Exam Question (Objective Questions), MCQ in English

Subjects : Concerned Subject, General Knowledge, Aptitude, Knowledge of Computer

Question Bank AIIMS CRE ARO / Research Assistant Exam - English

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Concerned Subject

Question 1Single Answer

Which organelle is the primary site of ATP production in eukaryotic cells?

A
Golgi apparatus
B
Mitochondrion
C
Endoplasmic reticulum
D
Lysosome

Question 2Single Answer

The rough endoplasmic reticulum is most directly involved in:

A
Lipid synthesis only
B
ATP generation
C
DNA replication
D
Protein synthesis destined for secretion or membrane insertion

Question 3Single Answer

Which structure forms the cell's boundary and regulates passage of substances?

A
Cytoskeleton
B
Lysosome
C
Nuclear envelope
D
Plasma membrane

Question 4Single Answer

The Golgi apparatus is primarily responsible for:

A
Energy production
B
DNA transcription
C
Protein glycosylation and sorting
D
Ribosomal RNA synthesis

Question 5Single Answer

Which organelle contains hydrolytic enzymes and is involved in intracellular digestion?

A
Peroxisome
B
Lysosome
C
Endosome
D
Ribosome

Question 6Single Answer

Which of the following is NOT a component of the cytoskeleton?

A
Microtubules
B
Intermediate filaments
C
Myelin sheath
D
Actin filaments

Question 7Single Answer

Peroxisomes are primarily involved in:

A
Beta-oxidation of very long-chain fatty acids and detoxification of hydrogen peroxide
B
Protein synthesis
C
DNA replication
D
Secretion of hormones

Question 8Single Answer

The smooth endoplasmic reticulum is specialized for:

A
Protein glycosylation
B
Chromosome segregation
C
ATP production
D
Lipid synthesis and detoxification

Question 9Single Answer

The nuclear pore complex functions to:

A
Allow transport of molecules between nucleus and cytoplasm
B
Synthesise RNA
C
Anchor chromosomes to the membrane
D
Produce ribosomes

Question 10Single Answer

Which of the following best describes chromatin in a non-dividing cell?

A
Highly condensed metaphase chromosomes
B
Located in mitochondria
C
Dispersed euchromatin and heterochromatin within the nucleus
D
Only RNA-based structure

Question 11Single Answer

Centrosomes function mainly in:

A
Energy metabolism
B
Microtubule nucleation and organization of the mitotic spindle
C
Protein secretion
D
Lipid storage

Question 12Single Answer

Which organelle synthesizes ribosomal RNA (rRNA)?

A
Smooth ER
B
Nucleolus
C
Golgi apparatus
D
Mitochondrion

Question 13Single Answer

Tight junctions between epithelial cells primarily:

A
Connect cytoskeletons of adjacent cells
B
Allow free diffusion of ions between cells
C
Create a selective barrier preventing paracellular flow
D
Anchor cells to the extracellular matrix

Question 14Single Answer

Desmosomes are important for:

A
Electrical coupling of cells
B
Transport of proteins into nucleus
C
Strong cell–cell adhesion resisting mechanical stress
D
Initiating apoptosis

Question 15Single Answer

Gap junctions allow passage of:

A
Ions and small metabolites for direct cell–cell communication
B
Large proteins between cells
C
DNA between nuclei
D
Lipids across membranes

Question 16Single Answer

Which membrane lipid is most abundant in the plasma membrane and forms the lipid bilayer?

A
Cholesterol
B
Triacylglycerol
C
Glycosphingolipids
D
Phospholipids

Question 17Single Answer

The outer membrane of mitochondria contains porins that:

A
Block all small molecules
B
Allow passage of molecules up to ~5 kDa
C
Are involved in ATP synthesis directly
D
Contain DNA for mitochondrial genes

Question 18Single Answer

Which organelle is involved in calcium storage and release in muscle cells?

A
Lysosome
B
Mitochondrion
C
Sarcoplasmic reticulum (a form of ER)
D
Peroxisome

Question 19Single Answer

The signal recognition particle (SRP) directs ribosomes to:

A
Mitochondria
B
Rough endoplasmic reticulum for co-translational import
C
Nucleus
D
Lysosomes

Question 20Single Answer

Which organelle is primarily responsible for synthesizing secreted and membrane proteins?

A
Smooth ER
B
Lysosome
C
Golgi apparatus
D
Rough ER

Question 21Single Answer

Which of these organelles contains its own circular DNA and ribosomes resembling bacterial ribosomes?

A
Mitochondria
B
Nucleus
C
Golgi apparatus
D
Lysosome

Question 22Single Answer

The primary function of clathrin-coated pits is:

A
ATP synthesis
B
Protein translation
C
Receptor-mediated endocytosis
D
Cytokinesis

Question 23Single Answer

Which organelle modifies and packages proteins and lipids for secretion or delivery?

A
Nucleus
B
Golgi apparatus
C
Mitochondrion
D
Peroxisome

Question 24Single Answer

Which organelle plays a major role in innate immune responses by breaking down pathogens taken into the cell?

A
Golgi apparatus
B
Peroxisome
C
Smooth ER
D
Lysosome

Question 25Single Answer

The basal body is structurally similar to:

A
Centriole
B
Mitochondrion
C
Nucleus
D
Golgi cisterna Correct

Question 26Single Answer

Which of the following is a double-membrane organelle?

A
Mitochondrion
B
Lysosome
C
Peroxisome
D
Ribosome

Question 27Single Answer

The endosomal system includes early endosomes, late endosomes and:

A
Chloroplasts
B
Nucleoli
C
Peroxisomes
D
Lysosomes

Question 28Single Answer

Which protein is the main structural component of microfilaments?

A
Tubulin
B
Keratin
C
Actin
D
Vinculin

Question 29Single Answer

Which of the following organelles is primarily involved in steroid hormone synthesis?

A
Rough ER
B
Smooth ER
C
Lysosome
D
Peroxisome

Question 30Single Answer

The protein import into mitochondria typically involves:

A
Signal peptides and translocases of outer and inner membranes (TOM/TIM complexes)
B
Nuclear pore complexes
C
Clathrin-mediated vesicles
D
Peroxisomal targeting signals only

Question 31Single Answer

Which of the following is NOT true about the nucleolus?

A
Site of rRNA transcription and ribosome assembly
B
Disassembles during mitosis
C
Contains dense fibrillar and granular components
D
Membrane-bound organelle

Question 32Single Answer

Which cellular junction provides mechanical linkage to the extracellular matrix via integrins?

A
Tight junction
B
Desmosome
C
Gap junction
D
Focal adhesion

Question 33Single Answer

Which structure in chloroplasts captures light energy in plants (note: relevant conceptual knowledge)?

A
Cristae
B
Golgi cisternae
C
Sarcoplasmic reticulum
D
Thylakoid membranes

Question 34Single Answer

The majority of protein glycosylation occurs in:

A
Nucleus
B
Mitochondria
C
Golgi apparatus and rough ER (N-linked begins in ER and processed in Golgi)
D
Peroxisomes

Question 35Single Answer

Autophagy involves delivery of cytoplasmic cargo to:

A
Lysosomes via autophagosomes
B
Peroxisomes
C
Golgi apparatus
D
Mitochondria

Question 36Single Answer

Which protein helps in vesicle fusion by forming SNARE complexes?

A
Clathrin
B
SNARE proteins (v-SNARE and t-SNARE)
C
Actin
D
Tubulin

Question 37Single Answer

The perinuclear space is located between:

A
Plasma membrane and cell wall
B
Mitochondrial membranes
C
Inner and outer nuclear membranes
D
ER lumen and Golgi lumen

Question 38Single Answer

Which organelle is the main site of lipid droplet formation and triacylglycerol storage?

A
Mitochondria
B
Endoplasmic reticulum
C
Lysosome
D
Ribosome

Question 39Single Answer

Which cellular organelle is most involved in antigen presentation via MHC class II pathway?

A
Golgi apparatus
B
Peroxisomes
C
Mitochondria
D
Endocytic/lysosomal compartments (MIIC)

Question 40Single Answer

What is the main role of chaperone proteins in the cell?

A
DNA replication
B
RNA splicing
C
Lipid transport
D
Assist folding of nascent and misfolded proteins

Question 41Single Answer

Which structure anchors the spindle microtubules during mitosis?

A
Nucleolus
B
Centrosome/centrioles
C
Golgi apparatus
D
Endoplasmic reticulum

Question 42Single Answer

Which organelle is primarily responsible for oxidative detoxification using catalase?

A
Lysosome
B
Mitochondrion
C
Peroxisome
D
Golgi apparatus

Question 43Single Answer

The main scaffold for cilia and flagella is the:

A
Actin filament network
B
Plasma membrane cholesterol domain
C
Intermediate filament core
D
Axoneme composed of microtubules (9+2 arrangement)

Question 44Single Answer

Which cellular compartment is associated with sphingolipid and glycolipid synthesis?

A
Nucleolus
B
Mitochondrial matrix
C
Smooth ER and Golgi apparatus
D
Lysosomal lumen

Question 45Single Answer

Signal peptides that target a protein for the secretory pathway are usually located:

A
At the C-terminus
B
Internally only
C
At the N-terminus
D
Only in the middle of the polypeptide

Question 46Single Answer

The endomembrane system includes which of the following?

A
ER, Golgi, endosomes, lysosomes, plasma membrane
B
Nucleus, mitochondria, chloroplasts
C
Ribosomes and peroxisomes only
D
Cytoskeleton and centrioles

Question 47Single Answer

The trans-Golgi network primarily functions in:

A
Entry point for proteins into the Golgi
B
Sorting and dispatching proteins to various destinations
C
DNA replication initiation
D
Ribosome assembly

Question 48Single Answer

Which organelle is primarily involved in gluconeogenesis in liver cells?

A
Mitochondria and cytosol (enzymes distributed)
B
Lysosome
C
Peroxisome only
D
Golgi apparatus

Question 49Single Answer

Lipid rafts in the plasma membrane are enriched in:

A
Unsaturated phospholipids only
B
DNA and RNA
C
Cholesterol and sphingolipids
D
ATP and ADP

Question 50Single Answer

Which cellular organelle's dysfunction is most directly implicated in lysosomal storage diseases?

A
Golgi apparatus
B
Endoplasmic reticulum
C
Mitochondria
D
Lysosome

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Concerned Subject

Question 51Single Answer

The primary role of the nuclear lamina is to:

A
Synthesize ATP
B
Degrade proteins
C
Provide structural support to the nuclear envelope and organize chromatin
D
Package lipids

Question 52Single Answer

Which organelle would you expect to be abundant in secretory cells producing digestive enzymes?

A
Smooth ER
B
Rough ER and Golgi apparatus
C
Mitochondria only
D
Peroxisomes only

Question 53Single Answer

Which feature distinguishes prokaryotic cells from eukaryotic cells?

A
Presence of membrane-bound nucleus in prokaryotes
B
Presence of mitochondria in prokaryotes
C
Absence of membrane-bound organelles in prokaryotes
D
Linear chromosomes in prokaryotes

Question 54Single Answer

During which phase of the cell cycle does DNA replication occur?

A
S phase
B
G1 phase
C
G2 phase
D
M phase

Question 55Single Answer

The checkpoint that ensures chromosomes are properly attached to the spindle before anaphase is the:

A
G1 checkpoint
B
Cytokinesis checkpoint
C
DNA damage checkpoint in S phase
D
Spindle assembly checkpoint (metaphase checkpoint)

Question 56Single Answer

Which protein complex cleaves cohesin to allow sister chromatid separation at anaphase?

A
Cyclin B
B
Separase (activated after securin degradation)
C
Condensin
D
Aurora kinase

Question 57Single Answer

Centrosome duplication occurs during:

A
S phase concurrent with DNA replication
B
G1 phase only
C
M phase only
D
Cytokinesis only

Question 58Single Answer

The anaphase-promoting complex (APC/C) primarily functions as:

A
An E3 ubiquitin ligase targeting proteins like securin for degradation
B
A kinase phosphorylating histones
C
A motor protein for spindle movement
D
A DNA polymerase complex

Question 59Single Answer

Which cyclin-CDK complex is critical for G1 to S transition?

A
Cyclin B–CDK1
B
Cyclin A–CDK1 only
C
Cyclin D–CDK4/6 and Cyclin E–CDK2 (promotes G1=S)
D
Cyclin C–CDK5

Question 60Single Answer

Which form of cell death is characterized by cell swelling and membrane rupture, often provoking inflammation?

A
Necrosis
B
Apoptosis
C
Autophagy
D
Anoikis

Question 61Single Answer

Apoptosis is often executed by which family of proteases?

A
Caspases
B
Kinases
C
Phosphatases
D
Helicases

Question 62Single Answer

In prophase of mitosis, chromosomes condense due to the action of:

A
Cohesins only
B
Ribosomes
C
DNA polymerase
D
Condensin complexes

Question 63Single Answer

Which signal transduction mechanism commonly uses GTP-binding proteins?

A
Receptor tyrosine kinases only
B
G-protein coupled receptors (GPCRs) activating heterotrimeric G proteins
C
Ion channels exclusively
D
Nuclear receptor ligand binding only

Question 64Single Answer

MAP kinase cascade typically culminates in activation of:

A
Transcription factors in the nucleus altering gene expression
B
Ion channels directly
C
Mitochondrial ATP production directly
D
Lysosomal degradation

Question 65Single Answer

The retinoblastoma protein (pRb) controls the G1 = S transition by:

A
Activating E2F transcription factors unconditionally
B
Phosphorylating DNA polymerase
C
Degrading cyclins directly
D
Binding and inhibiting E2F transcription factors when hypophosphorylated

Question 66Single Answer

Which of the following growth factor receptors has intrinsic tyrosine kinase activity?

A
GPCRs
B
Ionotropic receptors
C
Receptor tyrosine kinases (e.g., EGFR)
D
Nuclear hormone receptors

Question 67Single Answer

Contact inhibition of cell proliferation is mediated through:

A
Growth factor secretion only
B
Increased ATP production
C
Cell–cell adhesion signals and pathways that inhibit cell cycle progression
D
Mitochondrial fission

Question 68Single Answer

Which checkpoint responds to DNA double-strand breaks and can arrest the cell cycle?

A
DNA damage checkpoint involving ATM/ATR kinases
B
Spindle assembly checkpoint
C
Restriction point only
D
Cytokinesis checkpoint

Question 69Single Answer

Which phase of mitosis is characterized by alignment of chromosomes at the metaphase plate?

A
Prophase
B
Telophase
C
Anaphase
D
Metaphase

Question 70Single Answer

Which signaling molecule directly increases intracellular cAMP levels?

A
Tyrosine kinase receptor autophosphorylation
B
Phospholipase C activation
C
Adenylyl cyclase activation via Gs protein-coupled receptors
D
MAP kinase activation

Question 71Single Answer

Which protein family regulates apoptosis by controlling mitochondrial outer membrane permeabilization?

A
Heat shock proteins only
B
Cyclins
C
Bcl-2 family (pro- and anti-apoptotic members)
D
Integrins

Question 72Single Answer

Mitotic spindle microtubules that attach to kinetochores are called:

A
Astral microtubules
B
Interpolar microtubules only
C
Kinetochore microtubules (or K-fibers)
D
Actin filaments

Question 73Single Answer

Which small GTPase is important for vesicle formation and budding from membranes?

A
Ras
B
Myosin
C
Rab and Arf family GTPases (Arf involved in coat recruitment)
D
Cyclin-dependent kinase

Question 74Single Answer

The PI3K–AKT pathway is primarily associated with:

A
Inducing apoptosis
B
DNA replication machinery
C
Promoting cell survival, growth and metabolism
D
Lysosomal degradation

Question 75Single Answer

Which event defines the transition from metaphase to anaphase?

A
Chromosome condensation
B
Nuclear envelope formation
C
Cleavage of cohesin and separation of sister chromatids
D
DNA replication completion

Question 76Single Answer

Which kinase is the master regulator that triggers entry into mitosis (M phase)?

A
CDK2 only
B
CDK1 (complexed with Cyclin B)
C
PI3K only
D
MAPK only

Question 77Single Answer

Which process describes receptor downregulation after ligand binding?

A
Increased receptor synthesis
B
Mitochondrial sequestration
C
Nuclear import of receptor only
D
Receptor internalization and targeting to lysosomes for degradation

Question 78Single Answer

Which adhesion receptor family connects extracellular matrix to actin cytoskeleton?

A
Cadherins
B
Desmogleins
C
Connexins
D
Integrins

Question 79Single Answer

During meiosis I, homologous chromosomes separate during:

A
Anaphase II
B
Metaphase II
C
Anaphase I
D
Prophase II

Question 80Single Answer

The mitogen-activated protein kinase (MAPK) pathway often starts with:

A
G-protein activation only
B
Activation of receptor tyrosine kinases and recruitment of adaptor proteins like Grb2/SOS
C
Direct DNA binding of ligand
D
Ion channel opening exclusively

General Knowledge

Question 81Single Answer

Yojna a weekly journal

A
Ministry of Finance
B
Ministry of Information and Broadcastin
C
Ministry of Rural Development
D
Planning Commission

Question 82Single Answer

Kurukshetra a journal on rural development is published by

A
Ministry of Finance
B
Ministry of Information and Broadcastin
C
Ministry of Rural Development
D
Planning Commission

Question 83Single Answer

Devaluation of a currency means

A
Fixing the value of the currency in conjuction with the movement in the value of a basket of predetermined currencies
B
Reduction in the value of a currency vis-à-vis major internationally traded currencies
C
Fixing the value of currency in multilateral consultaion with the IMF the World Bank and major trading partners
D
Permitting the currency to seek its worth in the international market

Question 84Single Answer

Which is the national game of Bhutan ?

A
badminton
B
basketball
C
football
D
archery

Question 85Single Answer

Who is known as the "Missile Man of India"?

A
Dr. Homi J. Bhabha
B
Dr. Vikram Sarabhai
C
Dr. APJ Abdul Kalam
D
Dr. Satish Dhawan

Question 86Single Answer

What major defence-related development was highlighted on 1 May 2026 involving India and Italy?

A
Joint naval exercise in the Indian Ocean
B
Purchase of Rafale jets
C
Rajnath Singh-Italy Defence Pact
D
Signing of a nuclear agreement

Question 87Single Answer

Which satellite was launched by ISRO around early May 2026?

A
GSAT-31
B
Chandrayaan-4
C
INSAT-4CR
D
GSAT-32

Aptitude

Question 88Single Answer

The cash difference between the selling prices of an article at a profit of 4% and 6% is Rs. 3. The ratio of the two selling prices is:__________ ?

A
51:52
B
52:53
C
51:53
D
52:55

Question 89Single Answer

Which of the following numbers is irrational ?

A
√49
B
0.125
C
√2
D
22/7

Question 90Single Answer

356 x 936 – 356 x 836 = ?

A
35600
B
34500
C
9630
D
93600

Question 91Single Answer

Arrange in descending order: 5/8, 7/10, 3/4

A
3/4 > 7/10 > 5/8
B
7/10 > 3/4 > 5/8
C
3/4 > 5/8 > 7/10
D
5/8 > 7/10 > 3/4

Question 92Single Answer

What is (3^{^}{4} times 9^{^}{2}) ?

A
3⁶
B
3⁸
C
3¹⁰
D
9⁶

Question 93Single Answer

Passage :

information given below and answer the question that follow.
The result of an exam is given below. Out of 1000 students who appeared
(i) 658 failed in Physics
(ii) 166 failed in Physics and Chemistry
(iii) 372 failed in Chemistry, 434 failed in Physics and Maths
(iv) 590 failed in Maths, 126 failed in Maths & Chemistry
Find the number of people who failed in (assuming that none is passed in all subjects.

We have the following equations:
a+ b + c + d + e + f + g = 1000
a + b + d + e = 658, b + d = 166
b + d + c + f = 372
d + e = 434 as in the figure.
d + e + f + g = 590, d + f = 126. Find the values

Chemistry but not in Physics.

A
318
B
198
C
213
D
206

Question 94Single Answer

Passage :

Direction: information given below and answer the question that follow.
The result of an exam is given below. Out of 1000 students who appeared
(i) 658 failed in Physics
(ii) 166 failed in Physics and Chemistry
(iii) 372 failed in Chemistry, 434 failed in Physics and Maths
(iv) 590 failed in Maths, 126 failed in Maths & Chemistry
Find the number of people who failed in (assuming that none is passed in all subjects.

We have the following equations:
a+ b + c + d + e + f + g = 1000
a + b + d + e = 658, b + d = 166
b + d + c + f = 372
d + e = 434 as in the figure.
d + e + f + g = 590, d + f = 126. Find the values

Physics or Maths but not in Chemistry.

A
558
B
718
C
628
D
None of these

Knowledge of Computer

Question 95Single Answer

Which Windows interface element typically appears to display information, a warning, an error message, or a request for confirmation?

A
Window
B
Pop-up menu
C
Message box
D
Taskbar

Question 96Single Answer

What is active desktop ?

A
a term that is synonymous with viewing your desktop as web page
B
a feature to customize your desktop to display informating you can update from the internet
C
both a and b above mentioned
D
A software
E
None of these

Question 97Single Answer

What is meant by an active window?

A
A window that is minimized
B
The window currently receiving user input
C
Any window currently open
D
The window opened first

Question 98Single Answer

What was America Online (AOL) primarily known for during the early popularization of consumer Internet access?

A
An online service providing Internet access and proprietary online content
B
A computer operating system
C
A spreadsheet application
D
A database management system

Question 99Single Answer

An application is

A
word processing, accounting and engineering programs are example of application programs
B
computer program designed to enable users to perform specific job functions
C
Both a and b above mentioned
D
a document
E
None of these

Question 100Single Answer

Which of the following programs enables you to calculate numbers related to rows and columns?

A
Window program
B
Spreadsheet program
C
Graphics program
D
Word program
E
None of these

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Latest AIIMS CRE ARO Exam Question (Objective Questions), MCQ in English

Concerned Subject

AIIMS CRE ARO Exam Online Question Bank Package

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General Knowledge

Aptitude

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