Which preparation is used to help prevent dehydration or achieve rehydration?
A
Lytren solution
B
Liposul
C
Bicytra
D
Mylicon
Question 2Single Answer
Emulsions prepared using Tweens as the principal emulsifying agents are usually of which type?
A
Water-in-oil
B
Oil-in-water
C
Multiple emulsion
D
Microcapsule dispersion
E
reversible
Question 3Single Answer
Compared with the corresponding crystalline form, an amorphous form of a drug is generally?
A
Less soluble
B
More soluble
C
Chemically identical to a solvate
D
Completely insoluble
Question 4Single Answer
A triple-roller mill is particularly useful in pharmaceutical preparation for reducing particle size and producing smooth?
A
Ointments
B
Hard gelatin capsules
C
Aerosols
D
Suppository molds
Question 5Single Answer
Particle-size reduction is most likely to improve drug absorption when absorption is limited primarily by which process?
A
Dissolution of a poorly soluble drug
B
Renal filtration
C
Hepatic metabolism
D
Plasma-protein synthesis
Question 6Single Answer
A material whose apparent viscosity increases as shear rate increases is classified as?
A
Dilatant
B
Newtonian
C
Pseudoplastic
D
Thixotropic
Question 7Single Answer
A solution contains 3 grains of a drug per US fluid ounce. Approximately what is its percentage strength w/v?
A
0.66%
B
0.20%
C
1.50%
D
6.60%
Question 8Single Answer
Cyanocobalamin is which type of substance?
A
Steroid
B
Vitamin
C
Cholinesterase inhibitor
D
Enzyme
Question 9Single Answer
Tweens are best classified as which type of pharmaceutical excipient?
A
Nonionic surfactants
B
Phospholipids
C
Glycosides
D
Inorganic electrolytes
Question 10Single Answer
Which process can promote separation of an emulsion by accelerating movement of dispersed droplets?
A
Centrifugation
B
Buffering
C
Isotonization
D
Sweetening
Question 11Single Answer
Which gastrointestinal effect is characteristically associated with oral iron preparations?
A
Darkening of stools
B
Blue discoloration of saliva
C
Green discoloration of tears
D
Purple discoloration of sweat
Question 12Single Answer
Orally administered lidocaine has limited systemic usefulness largely because it undergoes extensive?
A
First-pass hepatic metabolism
B
Renal tubular secretion before absorption
C
Photochemical degradation in the stomach
D
Pulmonary metabolism before absorption
Question 13Single Answer
On exposure to air and light, phenol may gradually develop which discoloration because of oxidation?
A
Pink to reddish coloration
B
Bright green coloration
C
Deep blue coloration
D
Pure white coloration
Question 14Single Answer
Approximately how much HgCl₂ is required to prepare 1 US pint (about 473 mL) of a 1:5000 w/v solution?
A
9.5 mg
B
47.3 mg
C
94.6 mg
D
473 mg
Question 15Single Answer
Which sulfonylurea has historically been associated with potentiation of the antidiuretic action of vasopressin?
A
Chlorpropamide
B
Chloramphenicol
C
Phenytoin
D
Dicoumarol
Question 16Single Answer
Which two drug properties are commonly altered by pharmaceutical complexation?
A
Stability and solubility
B
Atomic number and density
C
Molecular formula and atomic mass
D
Radioactivity and isotopic abundance
Question 17Single Answer
If drug distribution into tissues occurs more slowly than elimination from plasma, what is most likely to occur initially?
A
Failure to rapidly attain distribution equilibrium
B
Immediate pharmacodynamic tolerance
C
Complete inhibition of metabolism
D
Irreversible plasma-protein binding
Question 18Single Answer
In pharmaceutical aerosol terminology, PSIG stands for?
A
Pounds per square inch gauge
B
Pressure standard in glass
C
Pounds per square inch gravity
D
Propellant strength in grams
Question 19Single Answer
In the older terminology of radiation protection, the abbreviation rem stands for?
A
Roentgen equivalent man
B
Radiation emission meter
C
Relative electron mass
D
Roentgen exposure measurement
Question 20Single Answer
Azathioprine is primarily classified as a?
A
Immunosuppressant
B
Cardiotonic
C
Antacid
D
Local anesthetic
Question 21Single Answer
Phenol has which property with respect to water at ordinary conditions?
A
It has appreciable but limited solubility in water
B
It is completely immiscible with water
C
It is a carboxylic acid
D
It is an inorganic base
Question 22Single Answer
The pH of an aqueous solution is fundamentally related to the activity of which ion?
A
Hydrogen ion
B
Sodium ion
C
Chloride ion
D
Calcium ion
Question 23Single Answer
Which tissue commonly serves as an important storage site for highly lipid-soluble drugs?
A
Adipose tissue
B
Corneal epithelium
C
Dental enamel
D
Nail plate
Question 24Single Answer
Extensive distribution or sequestration of a drug in tissues is commonly associated with which pharmacokinetic finding?
A
Large apparent volume of distribution
B
Zero clearance
C
Complete absence of metabolism
D
Very small apparent volume of distribution
Question 25Single Answer
Oxytocin may be administered clinically to?
A
Induce or augment labor
B
Prevent fertilization
C
Treat male hypogonadism
D
Produce chronic hypertension
Question 26Single Answer
Which antibiotic is acid-labile and therefore undergoes substantial degradation in the acidic environment of the stomach?
A
Penicillin G
B
Acetaminophen
C
Hydrocortisone
D
Aspirin
Question 27Single Answer
A surfactant can increase the dissolution of a poorly water-soluble drug primarily by improving?
A
Wetting and interfacial contact
B
Nuclear decay
C
Renal filtration pressure
D
Hepatic blood formation
Question 28Single Answer
Which drug is known to produce blue fluorescence of urine under ultraviolet light?
A
Triamterene
B
Riboflavin
C
Nitrofurantoin
D
Cascara
Question 29Single Answer
Extensive plasma-protein binding generally affects drug biotransformation by?
A
Slowing metabolism of the bound fraction
B
Completely preventing metabolite formation
C
Converting metabolism to renal filtration
D
Always accelerating hepatic metabolism
Question 30Single Answer
Celestone Soluspan contains formulations of which corticosteroid?
A
Betamethasone
B
Dexamethasone
C
Prednisone
D
Cortisone
Question 31Single Answer
The site and timing of drug release from an enteric-coated tablet depend strongly on gastrointestinal?
A
pH and transit conditions
B
Blood group
C
Respiratory rate alone
D
Skin temperature alone
Question 32Single Answer
Carbolic acid is another name for?
A
Phenol
B
Benzoic acid
C
Salicylic acid
D
Acetylsalicylic acid
Question 33Single Answer
Which dosage-form approach is commonly used to improve palatability by masking an unpleasant drug taste?
A
Taste-masking formulation
B
Increasing particle contamination
C
Removing all excipients
D
Increasing microbial load
Question 34Single Answer
Which medium used in compendial sterility testing is suitable for detecting fungi as well as aerobic bacteria?
A
Soybean–casein digest medium
B
Fluid thioglycollate medium only
C
Distilled water
D
Physiological saline alone
Question 35Single Answer
When a product contains an antimicrobial substance that could interfere with a sterility test, the test method should?
A
Neutralize or remove the antimicrobial activity appropriately
B
Automatically declare the product sterile
C
Omit incubation
D
Perform only a visual color test
Question 36Single Answer
Which medium is primarily intended for detection of anaerobic bacteria during compendial sterility testing?
A
Fluid thioglycollate medium
B
Purified water
C
Lactose solution
D
Mineral oil
Question 37Single Answer
Which factor can significantly alter the hepatic metabolism of another drug?
A
Enzyme induction or inhibition
B
Tablet color alone
C
Capsule shell color alone
D
Prescription handwriting style
Question 38Single Answer
What is the principal pharmaceutical role of potassium iodide in strong iodine solution?
A
Increasing the aqueous solubility of iodine
B
Acting as the main preservative
C
Increasing solution viscosity
D
Producing an emulsion
Question 39Single Answer
Which organic nitrate is commonly used for rapid relief of an acute anginal attack when administered sublingually?
A
Nitroglycerin
B
Warfarin
C
Digoxin
D
Hydrochlorothiazide
Question 40Single Answer
The usual adult dose of a drug is 6 grains. According to Young's rule, what dose is calculated for a 6-year-old child?
A
1 grain
B
2 grains
C
3 grains
D
4 grains
Question 41Single Answer
Which storage condition is appropriate for morphine sulfate tablets according to current product labeling?
A
Dispense in a tight, light-resistant container
B
Store permanently exposed to direct sunlight
C
Store in an open container
D
Immerse the tablets in water
Question 42Single Answer
Which plant is an important natural source of the anticancer vinca alkaloids vincristine and vinblastine?
A
Catharanthus roseus
B
Digitalis purpurea
C
Atropa belladonna
D
Strychnos nux-vomica
Question 43Single Answer
How much zinc sulfate is required to prepare 30 mL of a 1:500 w/v solution?
A
30 mg
B
60 mg
C
150 mg
D
500 mg
Question 44Single Answer
If a CNS-active drug is extensively ionized at blood pH, its passive penetration across the blood-brain barrier will generally be?
A
Slower
B
Faster
C
Independent of ionization
D
Instantaneous
Question 45Single Answer
Formation of a more soluble salt of an ionizable drug is commonly used primarily to improve its?
A
Aqueous solubility
B
Atomic number
C
Radioactivity
D
Isotopic composition
Question 46Single Answer
To reduce gastrointestinal irritation associated with niacin, patients are commonly advised to take immediate-release niacin?
A
With food
B
Only on an empty stomach
C
Only with antacids
D
Only after prolonged fasting
Question 47Single Answer
A drug with a biological half-life of 6.9 days would generally be expected to require which dosing pattern compared with a drug having a half-life of only a few hours, assuming other pharmacokinetic factors are similar?
A
Less frequent dosing
B
More frequent dosing
C
Continuous dosing every minute
D
A dosing interval unrelated to pharmacokinetics
Question 48Single Answer
Tween 20 is best classified as a?
A
Hydrophilic nonionic surfactant
B
Lipophilic ionic surfactant
C
Strong inorganic acid
D
Chelating metal ion
Question 49Single Answer
Which pharmacokinetic property does not directly determine the rate at which a drug is absorbed from a solution at its absorption site?
A
Elimination half-life
B
Solution viscosity
C
Drug complexation
D
Micellar solubilization
Question 50Single Answer
For a drug eliminated by first-order kinetics, the elimination half-life is given by which expression?
A
0.693/k
B
k/0.693
C
1/k²
D
2k
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Pharamedical
Question 51Single Answer
What is the primary purpose of parabens in pharmaceutical syrups?
A
Solubilizers
B
Preservatives
C
Buffers
D
Tonicity adjusters
Question 52Single Answer
Which of the following is an opioid analgesic?
A
Meperidine
B
Ibuprofen
C
Acetaminophen
D
Naproxen
Question 53Single Answer
Brij is a trade name associated with which type of pharmaceutical excipient?
A
Suspending agent
B
Surfactant
C
Propellant
D
Flavoring agent
Question 54Single Answer
Hemin used in Panhematin is derived from processed?
A
Red blood cells
B
Vitamin B12
C
Ferrous sulfate
D
Liver extract
Question 55Single Answer
Which substance has traditionally been used as a polishing agent in tablet coating?
A
Talc
B
Sodium chloride
C
Lactose
D
Calcium chloride
Question 56Single Answer
Sodium lauryl sulfate is commonly used in pharmaceutical formulations as a?
A
Wetting agent
B
Ketone
C
Preservative
D
Sweetening agent
Question 57Single Answer
A prescription requires 25 mmol of potassium chloride. How many grams of KCl are required if its molecular weight is 74.6 g/mol?
A
0.186 g
B
0.746 g
C
1.865 g
D
7.460 g
Question 58Single Answer
Approximately how many mEq of sodium are present in 1 liter of 0.9% sodium chloride solution before any additional sodium-containing drug is added?
A
77 mEq
B
100 mEq
C
154 mEq
D
308 mEq
Question 59Single Answer
Which statement about chloramphenicol is incorrect?
A
It is well absorbed orally
B
It penetrates many tissues effectively
C
It can cause serious hematologic toxicity
D
It is devoid of clinically important toxicity
Question 60Single Answer
How many grams of potassium sulfate (K₂SO₄; molecular weight ≈174.3) provide 10 mEq of K⁺?
A
0.087 g
B
0.436 g
C
0.872 g
D
1.743 g
Question 61Single Answer
How many milliliters of a 10% w/v KCl solution contain 5 mEq of K⁺ if the molecular weight of KCl is 74.6?
A
0.373 mL
B
1.865 mL
C
3.73 mL
D
7.46 mL
Question 62Single Answer
Gamma globulin fraction is separated from serum by
A
centrifugation
B
filtration
C
dialysis
D
salting out
E
agglutination
Question 63Single Answer
Which historically recognized advantage was associated with cyclacillin compared with ampicillin?
A
Lower incidence of diarrhea
B
Intravenous administration only
C
Complete resistance to all β-lactamases
D
Absence of antibacterial activity
Question 64Single Answer
Hashish is derived from the same plant source as?
A
Marijuana
B
Opium
C
Mescaline
D
LSD
Question 65Single Answer
A patient taking carisoprodol should particularly be cautioned that concomitant use of which substance may increase CNS depression?
A
Alcohol
B
Dietary fiber
C
Calcium-containing food
D
Vitamin C
Question 66Single Answer
Which statement correctly describes the interaction of tetracyclines with polyvalent metal ions?
A
They can chelate calcium, magnesium, aluminum, and iron ions
B
They interact only with sodium ions
C
They cannot form metal complexes
D
Metal ions always increase their gastrointestinal absorption
Question 67Single Answer
Most ionizable drugs used therapeutically behave as?
A
Strong electrolytes
B
Weak electrolytes
C
Permanently neutral compounds
D
Metallic conductors
Question 68Single Answer
Which chemical reaction is an important mechanism of degradation of susceptible drugs in the gastrointestinal tract?
A
Hydrolysis
B
Nuclear fission
C
Polymer crystallization
D
Sublimation
Question 69Single Answer
Sodium polystyrene sulfonate has historically been used primarily for?
A
Reducing elevated serum potassium
B
Treating scabies
C
Treating peptic ulcers
D
Producing local anesthesia
Question 70Single Answer
An isotonic solution with respect to red blood cells is one that ideally causes?
A
Neither hemolysis nor crenation
B
Hemolysis only
C
Crenation only
D
Irreversible erythrocyte precipitation
Question 71Single Answer
Hyaluronidase may be used as an adjunct to subcutaneous fluid or drug administration because it can?
A
Increase dispersion and absorption
B
Prevent all drug oxidation
C
Produce sustained release
D
Inhibit renal excretion
Question 72Single Answer
The commonly used buffer equation relating pH, pKa, and the ratio of conjugate base to acid is known as the?
A
Henderson-Hasselbalch equation
B
Stokes equation
C
Young equation
D
Noyes-Whitney equation
Question 73Single Answer
What is the approximate pKw of pure water at 25°C?
A
1
B
7
C
14
D
25
Question 74Single Answer
Edetate disodium has historically been used to reduce elevated levels of which ion?
A
Calcium
B
Sodium
C
Potassium
D
Lithium
Question 75Single Answer
Which type of drug requires metabolic conversion to an active compound before producing its intended therapeutic effect?
A
Prodrug
B
Antacid
C
Adsorbent
D
Osmotic laxative
Question 76Single Answer
Why should aspirin-containing tablets generally be protected from excessive moisture during storage?
A
Moisture promotes hydrolysis of aspirin
B
Moisture converts aspirin into penicillin
C
Moisture eliminates its molecular mass
D
Moisture makes aspirin radioactive
Question 77Single Answer
Benzalkonium chloride is incompatible with and may be inactivated by?
A
Anionic soaps
B
Purified water
C
Sodium chloride at physiological concentration
D
Glycerin alone
Question 78Single Answer
Chilling certain oral liquid medicines immediately before administration can primarily improve their?
A
Palatability
B
Ionization constant
C
Molecular weight
D
Renal clearance
Question 79Single Answer
Which administration strategy can maintain a controlled systemic input of a drug when continuous delivery is desired?
A
Intravenous infusion
B
Single topical dusting
C
Gargling followed by expectoration
D
External powder application
Question 80Single Answer
A chromogen is best defined as a substance that?
A
Can give rise to a colored compound
B
Fixes every dye permanently
C
Is necessarily a certified food dye
D
Must itself always be intensely colored
Question 81Single Answer
How many grams of aspirin are required to prepare 484 mL of a 12% w/v aspirin solution?
A
48.0 g
B
58.1 g
C
66.0 g
D
76.0 g
Question 82Single Answer
Hydrolysis of aspirin produces salicylic acid and which other substance?
Which radioisotope has classically been used in thyroid uptake studies?
A
Iodine-123
B
Carbon-12
C
Oxygen-16
D
Nitrogen-14
Question 86Single Answer
A solvent capable of both donating and accepting protons is described as?
A
Amphiprotic
B
Aprotic
C
Exclusively acidic
D
Exclusively basic
Question 87Single Answer
Glycerinated gelatin-type suppositories can be hardened using which soap-forming substance in traditional glycerin suppository formulations?
A
Sodium stearate
B
Sodium chloride
C
Calcium carbonate
D
Liquid paraffin
Question 88Single Answer
Why should silver nitrate preparations be protected from light?
A
Light promotes decomposition and darkening
B
Light converts silver into sodium
C
Light increases molecular weight
D
Light makes the preparation fluorescent blue
Question 89Single Answer
If a drug is eliminated both by excretion and metabolism through parallel first-order processes, its overall elimination rate constant is?
A
Sum of the individual elimination rate constants
B
Product of the rate constants
C
Difference between absorption and elimination constants
D
Equal only to the absorption rate constant
Question 90Single Answer
Which of the following is a Phase II drug-biotransformation reaction?
A
Glucuronide conjugation
B
Oxidation
C
Reduction
D
Hydrolysis
Question 91Single Answer
Which counseling point is appropriate for a drug known to cause harmless discoloration of urine?
A
Inform the patient beforehand about the expected discoloration
B
Automatically double the next dose
C
Stop all fluid intake
D
Crush every dose before administration
Question 92Single Answer
A major reason animal studies cannot perfectly predict human drug efficacy and toxicity is?
A
Species differences in drug metabolism
B
All animals have identical pharmacokinetics
C
Human and animal enzymes are always identical
D
Drug disposition is independent of species
Question 93Single Answer
Which sterilization method is suitable for heat-stable pharmaceutical powders such as talc?
A
Dry heat
B
Membrane filtration of the dry powder
C
Freeze-drying alone
D
Simple refrigeration
Question 94Single Answer
Hyperosmotic glycerin applied ophthalmically has historically been used to temporarily reduce corneal edema and thereby?
A
Improve corneal clarity
B
Produce permanent mydriasis
C
Produce permanent miosis
D
Stain the cornea
Question 95Single Answer
Which low-temperature gaseous sterilant has traditionally been used for heat-sensitive plastic medical devices?
A
Ethylene oxide
B
Direct flame
C
Boiling water only
D
Dry oven heat at very high temperature
Question 96Single Answer
Shrinkage of a gel accompanied by expulsion of liquid is called?
A
Syneresis
B
Coacervation
C
Dilatancy
D
Ebullition
Question 97Single Answer
Which packaging practice best protects a pharmaceutical oral liquid whose stability depends on its manufacturer-specified container system?
A
Dispense it in the required compatible container
B
Always transfer it to an open beaker
C
Remove the closure during storage
D
Expose it continuously to direct sunlight
Question 98Single Answer
Approximately how many milliliters of concentrated HCl containing 37% w/w HCl with a specific gravity of 1.18 are required to prepare 120 mL of a 5% w/v HCl solution?
A
6.9 mL
B
13.7 mL
C
27.4 mL
D
43.7 mL
Question 99Single Answer
The prescribed dose is 0.5 mg/kg. What dose should be given to a child weighing 44 lb?
A
5 mg
B
10 mg
C
20 mg
D
44 mg
Question 100Single Answer
Oleic acid is classified as a?
A
Monounsaturated fatty acid
B
Saturated fatty acid
C
Ketone
D
Carbohydrate
Question 101Single Answer
Rancidity of a fat is due to
A
oxidation
B
reduction
C
neutralization
D
hydrolysis
E
saponification
Question 102Single Answer
The minimal effective flow rate of air in laminar flow hoods should be not less than how many cubic feet per minute?
A
10
B
50
C
200
D
500
E
1000
Question 103Single Answer
Which of the following compounds of undecylenic acid is most commonly used in therapy?
A
Zinc
B
Magnesium
C
Manganese
D
Silver
E
Mercury
Question 104Single Answer
A vitamin which stains the urine is
A
vitamin D
B
thiamine
C
inositol
D
riboflavin
E
niacin
Question 105Single Answer
What effect does increased tissue storage have on biological half-life of drugs?
A
Makes it erratic
B
Renders it meaningless
C
Decreases it
D
Increases it
E
None
Question 106Single Answer
A 30 volume peroxide corresponds to
A
3% by weight
B
30% by weight
C
30% by volume
D
9% by weight
E
99% by weight
Question 107Single Answer
The Munsell system is associated with
A
flavor
B
odor
C
chemical classification
D
color
E
incompetibilities
Question 108Single Answer
The dose of a drug is 5 mg/kg of body weight. What dose should be given to a 110-Ib woman?
A
2 gr
B
4 gr
C
500 mg
D
5 gr
E
0.5 gr
Question 109Single Answer
The two most common proteins involved in plasma-protein binding are
A
barbiturates
B
globulin and plasmin
C
albumin and globulin
D
fibrinand plasmin
E
plasminogen and fibrin
Question 110Single Answer
Which of the following is classified as a loop diuretic?
A
Urea
B
Acetazolamide
C
Triamterene
D
Spironolactone
E
Furosemide
Question 111Single Answer
Diuretics tend to enhance lithium salt toxicity due to
A
sodium depletion
B
potassium depletion
C
direct drug interaction
D
increased absorption
E
increased solubility of the lithium salts
Question 112Single Answer
An oral antifungal agent is
A
zinc undecylenate
B
Tetrex
C
Desenex
D
griseofulvin
E
Sopronol
Question 113Single Answer
A disadvantage of sodium saccharin as a sweetening agent is
A
its bitter aftertaste
B
its solubility in water
C
its poor strength compared to glucose
D
its poor strength compared to dulcin
E
its toxicity
Question 114Single Answer
Responsibility for control of drugs covered by the drug abuse amendments falls upon
A
DEA
B
FTC
C
FDA
D
ICC
E
None of the above
Question 115Single Answer
Nitrofurantoin (Furadantin) is most active when the pH of the urinary tract is
A
neutral
B
over 9.5
C
between 6.0 and 7.0
D
5.5 or less
E
None of the above
Question 116Single Answer
Iodine is soluble in water in the presence of
A
sodium citrate
B
sodium sulfate
C
lactose
D
PVP
E
PEG
Question 117Single Answer
Povan could be classified as a
A
deflocculant
B
lubricant
C
cyanine dye
D
disintegrator
E
surfactant
Question 118Single Answer
Aloes are used to treat
A
burns
B
gastritis
C
blood dyscrasias
D
carcinomas
E
vertigo
Question 119Single Answer
The class of substances responsible for most accidental poisonings in children is
A
detergents
B
salicylate analgesics
C
bleaches
D
belladonna alkaloids
E
commercial dyes
Question 120Single Answer
Which of the following can cause discoloration of teeth?
A
Chloromycetin
B
Penicillin
C
Achromycin
D
Kanamycin
E
Sulfadiazine
Question 121Single Answer
Which of the following can increase the serum levels of penicillins significantly?
A
Salicylates
B
Probenicid
C
Antacids
D
Kaolin
E
Starches
Question 122Single Answer
Storage of soaking solutions for hard contact lenses should be
A
heated prior to use
B
acidified with weak acids
C
replaced weekly
D
replaced daily
E
None of the above
Question 123Single Answer
The principal limiting factor in the rate of absorption from suspensions is
A
dissolution rate
B
viscosity
C
the suspending agent
D
chemical stability
E
physical stability
Question 124Single Answer
Which of the following diuretics is quite effective even in the presence of electrolyte or acid-base imbalance?
A
Ethacrynic acid
B
Ammonium chloride
C
Chlorothiazide
D
Acetazolamide
E
None of the above
Question 125Single Answer
Ultrasonic waves have a frequency of
A
10-20 kc
B
20 kc or above
C
50 kc or above
D
over 100 kc
E
80-90 kc
Question 126Single Answer
Which of the following solutions should be sterile when dispensed?
A
Tinctures
B
Ophthalmic solutions
C
Spirits
D
Syrups
E
None of the above
Question 127Single Answer
Film coatings are
A
enteric coatings
B
sustained release
C
very brittle
D
very flexible
E
very thick
Question 128Single Answer
A type of bond frequently seen in complexes is
A
hydrogen bond
B
ionic bond
C
semipolar bond
D
double bond
E
triple bond
Question 129Single Answer
Which of the following agents may stain clothing when used topically?
A
Zinc oxide
B
Titanium dioxide
C
PAB
D
PAS
E
Undecylenic acid
Question 130Single Answer
Radioactive decay follows a
A
mixed order rate
B
fractional order rate
C
zero order rate
D
first order rate
E
second order rate
Question 131Single Answer
The HLB system is used to classify
A
flavors
B
colors
C
surfactants
D
organic ring structures
E
perfumes
Question 132Single Answer
In situ salt formation usually occurs
A
during in vivo distribution
B
before absorption
C
in storage sites
D
after biotransformation
E
in the kidney
Question 133Single Answer
Passive diffusion
A
can operate against a concentration gradient
B
is usually slow
C
required high energy
D
is usually quite fast
E
requires low energy
Question 134Single Answer
Glucagon may be used as a diagnostic agent in radiographic examination of the
A
bones
B
GI tract
C
liver
D
kidney
E
brain
Question 135Single Answer
A prevalent drug interaction of fluoride solutions involves
A
eggs
B
dairy products
C
meats
D
fish
E
many vegetables
Question 136Single Answer
Ostwald pipettes are used to measure
A
specific gravity
B
samples for assay
C
density
D
osmotic pressure
E
viscosity
Question 137Single Answer
Alpha particles are very similar to
A
hydrogen atoms
B
helium atoms
C
neutrons
D
protons
E
electrons
Question 138Single Answer
Gamma rays are very similar to
A
x-rays
B
alpharadiation
C
beta radiation
D
neutrinos
E
antineutrinos
Question 139Single Answer
A drug that reverses plasma-protein binding is often referred to as
A
a protein hydrolysate
B
a displacer
C
a solvate
D
a carrier substance
E
an enzyme
Question 140Single Answer
Patients using selenium sulfide should be warned that it should NOT be
A
used more than once a month
B
applied to wet hair
C
used after bleaching or tinting the hair
D
rinsed from hair for 30 minutes
E
used after soap shampoos
Question 141Single Answer
A rich source of vitamin A is
A
lean meats
B
bread
C
liver
D
poultry
E
fish liver oils
Question 142Single Answer
Contact angle is used to measure
A
moisture content of granules
B
spreadability of ointments
C
disintegration of tablets
D
coefficient of friction of powders
E
None of the above
Question 143Single Answer
According to Stokes law, the creaming of emulsions is indirectly proportional to
A
density of the dispersed phase
B
gravity
C
radius of dispersed phase
D
viscosity of the medium
E
None of the above
Question 144Single Answer
Plasma levels of vitamin A may be significantly affected by
A
vitamin D
B
oral contraceptives
C
cephalosporins
D
aspirin
E
Darvon-N
Question 145Single Answer
The most common disintegrator in compressed tablets is
A
dextrose
B
lactose
C
starch
D
potassium bitartrate
E
powdered sucrose
Question 146Single Answer
Freons are
A
alkanes
B
alkenes
C
alkynes
D
fluorinated hydrocarbons
E
mixture of CO2 and air
Question 147Single Answer
Agglomeration of particles in emulsions is often called
A
grouping
B
coalescence
C
dimerization
D
polymerization
E
dichromatism
Question 148Single Answer
Absorption of vitamin A from the GI tract depends on
A
the presence of bile in the intestine
B
which salt is used
C
acid-base balance
D
needs of the patient
E
pH of the intestine
Question 149Single Answer
Purity rubric means
A
purified coloring substance
B
Pure Food and Drug Act
C
USP or NF statement of required purity
D
substance requires purification
E
None of the above
Question 150Single Answer
Which of the following does NOT enhance complexation?
A
Gums
B
Cellulose derivatives
C
Polyols
D
Nonionic surfactants
E
Quaternary ammonium compounds
Question 151Single Answer
Which of the following factors may make it necessary to give lower doses of drugs to geriatric patients?
A
Reduction of enzyme activity
B
Reduced kidney function
C
Enhanced absorption
D
A and B
E
A, B and C
Question 152Single Answer
A drug that is frequently administered by inhalation is
A
insulin
B
isoproterenol
C
allopurinol
D
penicillin
E
nitroglycerin
Question 153Single Answer
FDA regulations requiring sealing of containers for OTC drugs resulted from contamination of Tylenol with
A
arsenic
B
cyanide
C
sympathomimetics
D
acids
E
bacterial toxins
Question 154Single Answer
Methotrexate should never be used concurrently with
A
penicillin
B
meprobamate
C
epinephrine
D
ethinamate
E
aspirin
Question 155Single Answer
Tablet hardness range is normally
A
0.2 – 0.5 kg
B
0.5 – 1.0 kg
C
1.0 – 2.0 kg
D
2.0 – 3.5 kg
E
3.5 – 7.0 kg
Question 156Single Answer
An antidote for heparin overdosage is
A
protamine sulfate
B
BAL
C
atropine
D
calcium salts
E
dicumarol
Question 157Single Answer
Anticoagulent acid citrate dextrose injection is required to be pyrogen-free. Pyrogens are
A
organic catalysts formed in living cells
B
antigens contained in bacteria
C
nonspecific globulins
D
products which stimulate hematopoietic organs
E
products causing febrile reaction upon injection
Question 158Single Answer
Weakly basic drugs are eliminated best under what conditions?
A
Alkaline urine
B
Acid urine
C
Neutral urine
D
Slowed biotransformation
E
Lack of biotransformation
Question 159Single Answer
Oral hypoglycemic are usually most useful in
A
juvenile diabetes
B
labile diabetes
C
brittle diabetes
D
late-onset diabetes
E
uncomplicated diabetes
Question 160Single Answer
Sulfinpyrazone (Antarane) frequently produces which of the following side effects?
A
Headache
B
Upper GI disturbances
C
Ringing in the ears
D
Respiratory depression
E
Diarrhea
Question 161Single Answer
Amyl nitrite is usually administered
A
by inhalation
B
sublingually
C
IM
D
IV
E
rectally
Question 162Single Answer
Capsicum is used in OTC liniments
A
to promote easy spreading
B
for its odor
C
to produce warmth or heat
D
as an analgesic
E
None of the above
Question 163Single Answer
Aluminum chloride is used mainly as a(an)
A
antiemetic
B
laxative
C
suspending agent
D
urinary acidifier
E
antiperspirant
Question 164Single Answer
A substance that is often used to subcoat tablet is
A
sugar
B
carnauba wax
C
shellac
D
sodium stearate
E
sodium chloride
Question 165Single Answer
Propranolol (Inderal) should be used only with extreme caution in patients suffering from
A
depression
B
cardiac arrhythmias
C
hypertension
D
hay fever
E
diabetes
Question 166Single Answer
When prescribing oral contraceptives, a physician need NOT give special attention to women who have
A
migraine headaches
B
diabetes
C
uterine tumors
D
never had a pregnancy
E
high blood pressure
Question 167Single Answer
Why are nitroglycerin tablets relatively unstable?
A
They become insoluble
B
They are hygroscopic
C
They are deliquescent
D
They drug migrates from the tablets
E
They tend to crumble
Question 168Single Answer
Antabuse is used to treat
A
diabetes
B
cholera
C
alcoholism
D
trench mouth
E
mumps
Question 169Single Answer
Passage :
Proposed changes in drug regulations must be published in which of the following is constitute official notice?
Proposed changes in drug regulations must be published in which of the following is constitute official notice?
A
Food and Drug Papers
B
Congressional Record
C
American Pharmaceutical Association Journal
D
Federal Register
E
All of the above
Question 170Single Answer
Which of the following is available in a metered dose aerosol?
A
Reserpine
B
Isoproterenol
C
Guanethidine
D
Dimenhydramine
E
Diphenylhydantoin
Question 171Single Answer
Benzoyl peroxide is used topically to treat
A
skin carcinomas
B
burns
C
minor abrasions
D
acne
E
dermatitis
Question 172Single Answer
Adjustment of dosage of diphenylhydantoin is based primarily on
A
patient response
B
blood levels
C
rate of excretion
D
body weight
E
prothrombin time
Question 173Single Answer
Darvon-N contains which of the following amounts of dextropropoxyphene napsylate?
A
50 mg
B
100 mg
C
32 mg
D
65 mg
E
None of the above
Question 174Single Answer
Which of the following best describes Schedule 1 drugs?
A
Most were formerly schedule A drugs
B
No accepted medical use in the U.S.
C
Used to be called exempt narcotics
D
Potent analgesics used to treat pain
E
Little potential for abuse
Question 175Single Answer
Which of the following is contraindicated with MAO inhibitors?
A
Milk
B
Cheeses
C
Cola beverages
D
Meats
E
Fish
Question 176Single Answer
Which of the following is NOT an advantage of aerosol dose forms?
A
Fine particle size
B
Easy to apply
C
Inexpensive
D
Even application
E
Less contamination
Question 177Single Answer
Which of the following may be used as plasma expanders?
A
Sodium salts
B
Dextrans
C
Starches
D
Calcium salts
E
Prostaglandins
Question 178Single Answer
. Aerosols should be stored at temperatures of
A
370 C or less
B
below 1200 F
C
below 950 F
D
below 1000 F
E
250 C or less
Question 179Single Answer
A prescription calls for 500 mg of digoxin dissolved in enough solvent to make 3 fluid ounces. How much of this solution will contain approximately 1/30 gr of ligoxin?
A
5 minims
B
4 minims
C
8 minims
D
10 minims
E
6 minims
Question 180Single Answer
Which of the following should be stored in dark glass bottles?
A
Silver nitrate solution
B
Lime water
C
Syrup U.S.P
D
Simple elixir
E
Coco-cola syrup
Question 181Single Answer
An antiemetic that contains principally carbohydrate derivatives is
A
Vesprin
B
Compazine
C
Tigan
D
Thorazine
E
Emetrol
Question 182Single Answer
Which of the following is used to offset the effects of coumarin derivatives?
A
Protamine sulfate
B
Adrenalin
C
Vitamin K
D
Calcium
E
BAL
Question 183Single Answer
Penicillamine is often classified as a(an)
A
antioxidant
B
chelating agent
C
micelle
D
surfactant
E
humectant
Question 184Single Answer
Prostaglandin E2 is used in the form of
A
tablets
B
capsules
C
solutions
D
vaginal suppositories
E
IV injections
Question 185Single Answer
Most volatile oils are rich in
A
terpenes
B
sulfur-containing compounds
C
fluorinated hydrocarbons
D
glucocorticoids
E
pyrimidines
Question 186Single Answer
A common evidence of deterioration of citrate of magnesia is
A
darkening of color
B
development of sour odor
C
precipitation
D
build up of excessive gas
E
lightening of color
Question 187Single Answer
Opium is obtained by
A
slitting capsules of a plant
B
extraction for leaves of a plant
C
grinding a plant
D
chemical synthesis
E
molecular modification
Question 188Single Answer
Tetrahydrazoline is used as a(an)
A
eyeglass protectant
B
contract lens solution
C
mitotic
D
mydriatic
E
ocular decongestant
Question 189Single Answer
Which of the following statistical techniques is(are) useful for clinical trials?
A
F test
B
Chi Square test
C
Latin Square
D
A and B
E
All of the above
Question 190Single Answer
Which of the following is NOT used as a binder for tablets?
A
Talc
B
Starch
C
Glucose
D
Sucrose
E
Gelatin
Question 191Single Answer
GMP regulations (USFDA) apply primarily to
A
controlled drugs
B
wholesalers
C
pharmaceutical manufacturers
D
hospital pharmacy
E
community pharmacy
Question 192Single Answer
pH is equivalent to pka at
A
pH of 7
B
pH of 1
C
pH of 14
D
half neutralization point
E
neutralization point
Question 193Single Answer
A method for removing pyrogens from water involves
A
oxidation with permanganate
B
oxidation with H2O2
C
precipitation with H2S
D
absorption of certain asbestos filter pads
E
None of the above
Question 194Single Answer
Splitting off of the face of a tablet is called
A
capping
B
fissuring
C
slugging
D
whiskering
E
picking
Question 195Single Answer
An instrument used to measure durability of tablets to shock and abrasion is a
A
tensiometer
B
dart penetrometer
C
chilsomator
D
brittleometer
E
friabilator
Question 196Single Answer
Titanium dioxide is used primarily as a
A
preservative
B
tablet hardener
C
sunscreen
D
surfactant
E
deflocculant
Question 197Single Answer
The nonaqueous vehicle used in injections is
A
alcohol
B
glycerol
C
alcoholic sodium stearate
D
vegetable oils
E
wax or liquid petrolatum
Question 198Single Answer
Which of the following drugs is commonly used to treat schistosomiasis?
A
Methylene blue
B
Praziquantel (Biltricide)
C
Emetine HCI
D
Chloroquine (Aralen)
E
Oxytetracycline (Terramycin)
Question 199Single Answer
Most tests of statistical significance are based on the
A
null hypothesis
B
mean
C
standard deviation
D
range
E
Chi Square test
Question 200Single Answer
An advantage of allopurinol (Zyloprin) over may uricosuric is that is
