OPSC Assistant Professor (Pathology) Syllabus 2026, Exam Pattern, Exam Date 2026
Detail Information about OPSC has published notification 2026 for the recruitment of Assistant Professor (Pathology) vacancies. Those Candidates who are Interested to the following vacancy and completed all Eligibility Criteria can read the Notification & Apply Online. In this page we provide the Complete Syllabus of this Recruitment with Latest Update Exam Pattern and the Exam Date also.
OPSC Assistant Professor (Pathology) Syllabus 2026 - Overview
| Organization Name |
Odisha Public Service Commission (OPSC) |
| Post Name |
Assistant Professor (Broad Speciality) |
| Total Vacancies |
31 |
| Application Mode |
Online |
| Category |
Syllabus and Exam Pattern |
| Exam Date 2026 |
22nd February 2026 |
| Selection Process |
Written Test |
| Job Location |
Government MCHs, Odisha |
| Official Website |
https://opsc.gov.in |
OPSC Assistant Professor (Pathology) Syllabus 2026
Concerned Subject (Pathology) :
A. General Pathology and Pathophysiology:
1. Cell Injury, Cell Death, and Adaptations:
Causes and mechanisms of cell injury (hypoxia, toxins, physical agents, etc.).
Reversible and irreversible cell injury.
Cellular adaptations (atrophy, hypertrophy, hyperplasia, metaplasia, dysplasia).
Apoptosis and Necrosis (types, mechanisms, differences).
Subcellular responses to injury.
Intracellular accumulations (lipids, proteins, glycogen, pigments, etc.).
Pathological calcification.
Cellular aging.
2. Inflammation and Repair:
Acute inflammation (vascular and cellular events, mediators, outcomes).
Chronic inflammation (causes, morphology, granulomatous inflammation).
Tissue repair: Regeneration, wound healing (primary and secondary intention), fibrosis.
Factors influencing wound healing.
3. Hemodynamic Disorders, Thromboembolic Disease, and Shock:
Edema (types, pathogenesis).
Hyperemia and congestion.
Hemorrhage.
Thrombosis (pathogenesis, types, fate of thrombi).
Embolism (types, consequences).
Infarction.
Shock (types, pathogenesis, stages, morphological changes).
4. Genetic Disorders:
Basic principles of medical genetics.
Chromosomal disorders (numerical and structural abnormalities, common syndromes).
Single gene disorders (autosomal dominant, autosomal recessive, X-linked, mitochondrial).
Multifactorial inheritance.
Molecular diagnostics in genetic diseases.
5. Immunopathology:
Basic immunology (innate and adaptive immunity, cells and molecules of immune system).
Hypersensitivity reactions (Types I, II, III, IV).
Autoimmune diseases (mechanisms, common examples).
Immunodeficiency disorders (primary and secondary).
Transplantation immunology (MHC, graft rejection).
Amyloidosis.
6. Neoplasia:
Nomenclature and classification of tumors (benign and malignant).
Epidemiology of cancer.
Molecular basis of cancer (oncogenes, tumor suppressor genes, DNA repair genes, microRNAs).
Carcinogenesis (chemical, physical, microbial).
Tumor growth and spread (invasion, metastasis).
Grading and staging of cancer.
Host defense against tumors.
Paraneoplastic syndromes.
Laboratory diagnosis of cancer (histopathology, cytology, immunohistochemistry, molecular diagnostics, tumor markers).
7. Infectious Diseases:
Mechanisms of microbial pathogenesis.
Host responses to infection.
Specific infections (bacterial, viral, fungal, parasitic – emphasis on pathological aspects).
Emerging and re-emerging infectious diseases.
8. Environmental and Nutritional Pathology:
Environmental toxins (air pollutants, heavy metals, pesticides).
Drug-induced injuries.
Physical agents (radiation, heat, cold, mechanical trauma).
Nutritional deficiencies and excesses.
B. Systemic Pathology:
1. Cardiovascular System: Atherosclerosis, hypertension, ischemic heart disease, valvular heart disease, cardiomyopathies, congenital heart diseases, pericardial diseases, vascular tumors.
2. Respiratory System: Pneumonia, tuberculosis, chronic obstructive pulmonary disease (COPD), asthma, interstitial lung diseases, lung cancer, pleural diseases.
3. Renal and Urinary Tract System: Glomerular diseases, tubular and interstitial diseases, acute kidney injury, chronic kidney disease, urinary tract infections, renal cell carcinoma, bladder cancer.
4. Gastrointestinal Tract: Esophagitis, gastritis, peptic ulcer disease, inflammatory bowel disease (Crohn's, Ulcerative Colitis), colorectal cancer, polyps, appendicitis, diverticular disease.
5. Liver, Biliary Tract, and Pancreas: Hepatitis (viral, alcoholic, autoimmune), cirrhosis, liver tumors, cholelithiasis, cholecystitis, pancreatic pathologies (pancreatitis, pancreatic cancer).
6. Hematopoietic and Lymphoid System:
Anemias (iron deficiency, megaloblastic, hemolytic, aplastic).
Myeloproliferative neoplasms (CML, polycythemia vera, essential thrombocythemia, primary myelofibrosis).
Myelodysplastic syndromes.
Acute and chronic leukemias.
Lymphomas (Hodgkin, Non-Hodgkin).
Plasma cell disorders (multiple myeloma).
Histiocytoses.
Bleeding and clotting disorders (coagulopathies, thrombotic disorders).
7. Male Genital System: Prostatic hyperplasia, prostate cancer, testicular tumors.
8. Female Genital System: Cervical pathology (CIN, carcinoma), endometrial hyperplasia and carcinoma, ovarian tumors, gestational trophoblastic disease.
9. Breast: Fibrocystic changes, fibroadenoma, carcinoma of the breast.
10. Endocrine System: Pituitary adenomas, thyroid disorders (goiter, thyroiditis, tumors), parathyroid disorders, adrenal cortical and medullary disorders, diabetes mellitus (pathology of complications).
11. Skin: Inflammatory dermatoses (eczema, psoriasis), infections, melanocytic nevi, melanoma, basal cell carcinoma, squamous cell carcinoma.
12. Musculoskeletal System: Osteomyelitis, osteoporosis, Paget's disease, osteosarcoma, soft tissue tumors, arthritis.
13. Central Nervous System: Cerebrovascular diseases (stroke, hemorrhage), infections (meningitis, encephalitis), neurodegenerative diseases (Alzheimer's, Parkinson's), demyelinating diseases (MS), CNS tumors.
C. Histopathology and Cytopathology:
1. Tissue Processing and Staining: Fixation, grossing, processing (dehydration, clearing, embedding), microtomy, routine H&E staining, special stains (e.g., PAS, Masson's Trichrome, Reticulin, Congo Red, Perl's, Alcian Blue).
2. Immunohistochemistry (IHC): Principles, common markers and their applications in diagnosis and prognostication of tumors (e.g., cytokeratins, vimentin, desmin, S100, CD markers, ER/PR, HER2).
3. Frozen Section: Principles, technique, common indications, limitations, and interpretation.
4. Cytopathology:
Principles of cytodiagnosis.
Sampling techniques (FNAC, exfoliative cytology).
Processing and staining of cytological smears (Papanicolaou, MGG).
Interpretation of cytology from various sites:
Gynecological (Pap smear, Bethesda system).
Respiratory (sputum, bronchial wash/brush).
Urinary (urine cytology).
Serous effusions (pleural, peritoneal, pericardial fluid).
Cerebrospinal fluid (CSF).
Thyroid, salivary gland, lymph node, breast, soft tissue FNAC.
5. Renal Biopsy Pathology: Interpretation of kidney biopsies (light microscopy, immunofluorescence, electron microscopy).
D. Hematology and Transfusion Medicine:
1. Hematopoiesis: Stem cell biology, myeloid and lymphoid differentiation.
2. Red Blood Cell Disorders: Anemias (morphological and etiological classification), polycythemia.
3. White Blood Cell Disorders: Leukemias (acute and chronic myeloid/lymphoid), lymphomas, plasma cell dyscrasias, myelodysplastic syndromes, myeloproliferative neoplasms.
4. Platelet and Coagulation Disorders: Thrombocytopenia, thrombocytosis, disorders of platelet function, coagulation factor deficiencies (hemophilia), disseminated intravascular coagulation (DIC), thrombotic disorders.
5. Bone Marrow Examination: Indications, procedure, interpretation (aspirate and biopsy).
6. Special Hematology Tests: Flow cytometry, cytogenetics, molecular diagnostics in hematological malignancies.
7. Transfusion Medicine (Blood Banking):
Blood groups and cross-matching.
Donor selection and blood collection.
Component preparation and storage.
Transfusion reactions (types, management, prevention).
Hemolytic disease of the newborn (HDN).
Apheresis.
Quality control in blood banking.
E. Clinical Pathology and Laboratory Medicine:
1. Urine Examination: Physical, chemical, and microscopic examination.
2. Stool Examination: Gross, microscopic, and chemical tests.
3. Semen Analysis.
4. CSF and other Body Fluid Analysis: Macroscopic, microscopic, and biochemical analysis of pleural, peritoneal, pericardial, synovial fluids.
5. Basic Principles of Clinical Biochemistry: Renal function tests, liver function tests, blood glucose, electrolytes, serum proteins, enzymes. (While a pathologist does not perform these tests, understanding the principles and interpretation of abnormalities is crucial for correlation with pathological findings).
6. Quality Control in Laboratory: Internal and external quality control, laboratory accreditation, good laboratory practices (GLP), laboratory safety.
7. Lab Management: Inventory management, waste disposal.
F. Autopsy Pathology:
Medico-legal and clinical autopsies.
Procedures, techniques, and interpretation of findings.
Documentation and reporting.
Forensic aspects of autopsy.
G. Recent Advances and Applied Aspects:
Molecular Pathology: PCR, FISH, gene sequencing, microarrays, next-generation sequencing and their applications in diagnosis and prognosis.
Digital Pathology and Telepathology.
Artificial Intelligence in Pathology.
Emerging diagnostic techniques and biomarkers.
Biobanking and ethical issues in pathology.
Quality management systems in laboratories (NABL accreditation).
OPSC Assistant Professor (Pathology) Exam Pattern 2026
Duration : 180 Minutes
Negative Marking : 0.25
| S.No |
Subject |
No.of Question |
Marks |
| 1 |
Concerned Subject (Pathology) |
200 |
200 |
| |
Total |
200 |
200 |
Exam Date 2026 : 22nd February 2026
Starting Date of Application Form : 27th January 2026
Last Date of Application Form : 03rd February 2026 
